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Histopathology SOP template library
Editable, print-ready SOP templates covering the histopathology workflow — receiving, fixation, grossing, processing, embedding, microtomy, staining, IHC pre-analytical and reagent safety. Adapt each to your laboratory.
📄 Tissue Receiving & Accessioning SOP
To ensure every specimen is received, identified and registered accurately with full trace📄 Fixation SOP
To standardise fixation so morphology and antigenicity are preserved.📄 Grossing / Cut-up SOP
To describe and sample specimens systematically for diagnosis.📄 Tissue Processing SOP
To dehydrate, clear and infiltrate tissue with paraffin for sectioning.📄 Embedding SOP
To orient and embed tissue in paraffin blocks correctly.📄 Microtomy SOP
To cut and mount high-quality paraffin sections.📄 Floatation (Water) Bath SOP
To operate and maintain the floatation bath for section expansion.📄 Slide Warming / Drying SOP
To dry sections adequately for adhesion before staining.📄 H&E Staining SOP
To produce consistent haematoxylin and eosin staining.📄 IHC Pre-Analytical SOP
To control pre-analytical factors that affect IHC results.📄 Formalin Handling & Safety SOP
To handle formaldehyde safely and limit exposure.📄 Xylene Handling & Safety SOP
To handle xylene (or substitute clearants) safely.📄 Reagent & Wax Change SOP
To maintain reagent quality by scheduled rotation and change.📄 Slide & Block Archiving / Retention SOP
To ensure proper archiving and retention of histopathology slides and blocks for future re📄 Cytology Specimen Fixation SOP
To ensure proper fixation of cytology specimens for optimal preservation and accurate anal📄 FNA Sample Handling SOP
To outline the proper handling and processing of Fine Needle Aspiration (FNA) samples in c📄 Fluid / Effusion Cytology Processing SOP
To outline the standardized procedure for processing fluid and effusion cytology samples t📄 Pap Smear Staining SOP
To outline the standardized procedure for staining Pap smears in cytology to ensure consis📄 Liquid-Based Cytology SOP
To outline the standardized procedures for performing liquid-based cytology to ensure accu📄 Whole-Slide Imaging & Validation SOP
To outline the procedures for whole-slide imaging and validation to ensure accurate digita📄 Mounting & Coverslipping SOP
To ensure proper mounting and coverslipping of histological slides to preserve tissue morp📄 Frozen Section (Intra-operative) SOP
To outline the procedure for performing frozen section analysis during intra-operative con📄 Gross Photography SOP
To ensure standardized procedures for capturing high-quality gross photographs of specimen📄 Cassette & Slide Labelling / Traceability SOP
To ensure accurate labelling and traceability of cassettes and slides during the grossing📄 Antigen Retrieval SOP
To outline the procedure for antigen retrieval in immunohistochemistry (IHC) to enhance an📄 Immunohistochemistry Staining SOP
To outline the standardized procedure for performing immunohistochemistry staining to ensu📄 IHC Antibody Validation SOP
To ensure the reliability and accuracy of immunohistochemistry (IHC) results through syste📄 Molecular Pathology Pre-Analytical SOP
To outline the pre-analytical processes for handling and processing molecular pathology sp📄 Internal Quality Control SOP
To ensure the accuracy and reliability of test results through systematic internal quality📄 External Quality Assessment (EQA / PT) SOP
To ensure the laboratory's performance is evaluated against external standards and to prom📄 Temperature & Humidity Monitoring SOP
To ensure that temperature and humidity levels in the laboratory are maintained within spe📄 Equipment Calibration & Verification SOP
To ensure all laboratory equipment is calibrated and verified for accurate performance and📄 Preventive Maintenance SOP
To ensure that all laboratory equipment is functioning optimally and to prevent unexpected📄 Staff Competency Assessment SOP
To ensure that all laboratory staff possess the necessary skills and knowledge to perform📄 Document Control SOP
To ensure that all documents related to quality management are properly controlled and mai📄 Non-Conformance & Corrective Action SOP
To outline the process for identifying, documenting, and addressing non-conformances to en📄 Turnaround-Time Monitoring SOP
To establish a standardized process for monitoring and improving turnaround times in histo📄 Biomedical Waste Segregation & Disposal SOP
To establish guidelines for the proper segregation and disposal of biomedical waste to ens📄 Chemical Spill Response SOP
To outline the procedures for responding to chemical spills to ensure safety and minimize📄 PPE & Laboratory Safety SOP
To ensure the safety of laboratory personnel by outlining the proper use of personal prote📄 Decalcification SOP
To outline the procedure for decalcifying bone specimens to ensure optimal histological pr📄 Specimen Transport & Cold Chain SOP
To ensure the proper transport and maintenance of specimens under cold chain conditions to📄 Sample Rejection Criteria SOP
To outline the criteria for rejecting specimens that do not meet quality standards for his📄 Critical / Panic Value Communication SOP
To ensure timely communication of critical/panic values to appropriate personnel for immed📄 Special Stains (General) SOP
To outline the procedures for performing special stains in histopathology to ensure consis📄 PAS Staining SOP
To provide a standardized method for performing Periodic Acid-Schiff (PAS) staining to ide📄 Masson Trichrome Staining SOP
To provide a standardized method for Masson Trichrome staining to differentiate collagen f📄 Ziehl-Neelsen (AFB) Staining SOP
To outline the procedure for performing Ziehl-Neelsen staining to identify acid-fast bacil📄 Reticulin Staining SOP
To provide a standardized method for performing reticulin staining in histopathology to viThis is a template for educational and planning purposes. Laboratories must adapt it to their institutional SOPs, manufacturer instructions, applicable accreditation requirements, and pathologist approval before use.