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Student — Today's case

🎓 Student track Simulated educational case

Spot diagnosis: nests of cells with keratin pearls

Head & neck / skin

Simulated educational case. An H&E section from a skin/mucosal biopsy (adult age range) shows irregular nests and sheets of atypical squamous cells infiltrating the dermis. There are intercellular bridges and concentric whorls of pink keratin (keratin pearls). Mitoses are present.

Question: What is the most likely diagnosis, and what two morphological clues support it?

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Your answer

⚠ For educational peer discussion only. This is not a patient-specific diagnostic consultation. Do not submit any patient-identifiable information.

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