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Knowledge BaseTroubleshooting Atlas › Quality & QC

Calibration drift on temperature-critical equipment

What it looks like

Calibration drift may result in inaccurate temperature readings, affecting the quality of samples processed. This can lead to inconsistent staining or preservation of histological features.

Where it usually appears: Typically observed during routine quality control checks or after maintenance on temperature-sensitive equipment like embedding centers or microtomes.

Likely causes
  • Improper calibration procedures
  • Environmental temperature fluctuations
  • Equipment age or wear
  • Power supply issues
Immediate checks
  • Verify current temperature readings
  • Check calibration logs
  • Inspect power connections
Corrective action
  • Recalibrate the equipment
  • Replace faulty components
  • Adjust environmental controls
Preventive action
  • Establish a regular calibration schedule
  • Implement temperature monitoring systems
  • Train staff on proper equipment handling
Equipment: Embedding centers, microtomes, refrigeratorsRelated SOP: Temperature Calibration SOP

This atlas is for educational purposes for laboratory professionals. It does not replace your institutional SOPs, manufacturer instructions, validated protocols or pathologist judgment. Adapt any action to your laboratory and equipment.

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