Knowledge Base › Troubleshooting Atlas › Microtomy
Block advances unevenly (feed/advance drift)
Also known as: feed drift, uneven block advance
What it looks like
Tissue sections may appear thicker on one side and thinner on the other, resulting in uneven cut quality.
Where it usually appears: Commonly observed during routine microtomy when cutting large or dense blocks.
Likely causes
- Block is not properly oriented
- Blade dull or damaged
- Inconsistent pressure applied during cutting
- Microtome settings not calibrated
- Block temperature too low
Immediate checks
- Inspect block orientation
- Examine blade for damage or wear
- Check microtome settings for accuracy
Corrective action
- Reorient the block properly
- Replace or sharpen the blade
- Adjust cutting pressure during sectioning
Preventive action
- Regularly calibrate microtome
- Ensure proper block embedding technique
- Perform routine maintenance on blades
This atlas is for educational purposes for laboratory professionals. It does not replace your institutional SOPs, manufacturer instructions, validated protocols or pathologist judgment. Adapt any action to your laboratory and equipment.
Unimeditrek supports histopathology laboratories with tissue processors, microtomes, staining and workflow equipment plus service and AMC. Talk to a specialist →